Pupils are referred to the school with written support from a range of professionals, following a Common Assessment Framework and/or Child Well Being meeting. Some pupils have a Statement of Special Educational Need. Those attending the Wrenthorpe Centre have a variety of medical conditions, including mental health problems, such as anxiety, depression, phobias or eating disorders. The needs of pupils with mental health problems, which lead them to display aggression to others, cannot be met at Pinderfields Hospital School.

Pupils attending the Wrenthorpe Centre have an Individual Plan setting out their personal targets in addition to academic targets.  A broad and balanced alternative curriculum is delivered, which offers opportunities to gain a range of accreditation. The school is a registered examination centre. A wide range of enrichment experiences are also offered including sporting activities and residential visits, which are facilitated by the use of the school minibus.